Research Paper On Vaccines

Research Paper On Vaccines-60
The coding classification used in the study period was the International Classification of Diseases, 10th Revision; we used the codes F84.0 (autistic disorder), F84.1 (atypical autism), F84.5 (Asperger syndrome), F84.8 (other pervasive developmental disorder), and F84.9 (unspecified pervasive developmental disorder).We defined our main study outcome of autism as a diagnosis of any of these autism spectrum disorders.

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Research Paper On Vaccines

Of these, 2 cohort studies and 4 case–control studies specifically addressed MMR and autism, all reporting no association.During 5 025 754 person-years of follow-up, 6517 children were diagnosed with autism (incidence rate, 129.7 per 100 000 person-years).Comparing MMR-vaccinated with MMR-unvaccinated children yielded a fully adjusted autism hazard ratio of 0.93 (95% CI, 0.85 to 1.02).Another criticism has been that MMR is associated with a regressive form of autism, leading to a clustering of cases with onset shortly after MMR vaccination (7).We evaluate the risk for autism after MMR vaccination in specific periods in detail.From the Danish National Patient Register comprising diagnoses from all somatic departments, we obtained information on several syndromes and conditions with an inherent increased risk for autism (fragile X syndrome, tuberous sclerosis, Angelman syndrome, Down syndrome, Di George syndrome, neurofibromatosis, Prader–Willi syndrome, and congenital rubella syndrome) (11).Children with any of these conditions were excluded from the study if the condition was diagnosed before their first birthday or censored at date of the diagnosis if it was made when the child was older than 1 year (14).This is consistent with more recent studies of note (3, 4).We previously addressed this issue in a nationwide cohort study of 537 303 Danish children with 738 cases of autism spectrum disorders (5).Table 1 of the Supplement provides a complete list of variables with categorizations).These variables were obtained from the Danish Medical Birth Registry, which includes information on the parents and the newborn, pregnancy, date of birth, multiple births, gestational age, and vital status and other physical characteristics of the newborn (13).


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